The Callisto Protocol throws you into the unforgiving Black Iron Prison, a maximum security facility on Jupiter’s moon. As Jacob Lee, you’ll fight for survival against mutated Biophages and uncover the dark secrets of the prison. This walkthrough will guide you through the main story, highlighting key objectives, combat encounters, and exploration opportunities.
This walkthrough is for the main story path and assumes a standard difficulty setting.
The Callisto Protocol is a linear experience with limited exploration, so the focus will be on navigating key story beats and combat encounters.
For a complete 100% walkthrough with collectibles and secrets, refer to online resources.
Cargo
Introduction: The game opens with Jacob and his partner, Dani, transporting a mysterious cargo. A security alert throws things into chaos, and you’re separated from Dani.
Following the Protocol: Head through the corridors, following the yellow quarantine markers. Interact with the panel to open the door and proceed.
Medical Checkup: Get strapped into the medical chair. This is a scripted sequence, introducing you to the prison’s “rehabilitation” methods.
Cell Block: After the medical bay, you’ll find yourself in your cell. A short cutscene introduces the unsettling reality of Black Iron.
Riot: A loud bang signals a prison riot. Follow the commotion and escape through the ventilation shaft.
Outbreak
Escape Tunnel: Crawl through the ventilation shaft, emerging into a dark service tunnel. Look out for lootable containers with credits and crafting materials.
First Encounter: You’ll encounter your first Biophage. Melee attacks are effective at this stage. Grab a nearby pipe for close combat.
Following the Warden: Follow the path, encountering more Biophages. Use melee attacks and dodge their attacks to survive.
Reaching the Surface: Take the elevator to the surface, witnessing the extent of the Biophage outbreak.
Guarded Gate: A security gate is locked. Head to the control room on the right and activate the override switch.
Aftermath
Ruined Settlement: Explore the ruined settlement, scavenging for credits and crafting materials. You’ll also find a downed security officer who provides some backstory.
Gun Acquisition: Enter a building and grab a pistol from a security locker. This is your first ranged weapon.
Biophage Horde: Prepare for a large group of Biophages. Use the pistol to take down enemies from a distance, focusing on weak points for faster kills.
Underground Tunnels: Descend into the underground tunnels, encountering more Biophages and mutated humans.
Biomass and GRP Gun: You’ll encounter glowing red Biomass for the first time. Collect it to craft healing items and GRP ammo. Find a GRP gun nearby – this weapon can grab and throw enemies.
Habitat
Habitat Arrival: After navigating the tunnels, you’ll arrive at a seemingly abandoned habitat.
Exploring the Habitat: Search for credits, crafting materials, and Biomass. Interact with terminals for additional lore entries.
Hunting for a Keycard: Locate a keycard needed to progress. Explore the upper levels of the habitat, fighting mutated creatures and avoiding environmental hazards.
Elevator Ride: Use the acquired keycard to access the elevator and descend further.
Boss Fight: Captain Ferris: You’ll encounter a mutated Captain Ferris. Dodge his attacks and use a combination of pistol, GRP gun, and melee attacks to take him down.
Lost
Zero-Gravity Walkway: Navigate the zero-gravity walkway, using strategically placed boosters to propel yourself.
Exploring the Derelict Ship: Enter a derelict ship, encountering more Biophages and mutated creatures. Look for environmental hazards and utilize them to your advantage.
Finding the Artifact: Locate a mysterious artifact that seems to be connected to the Biophage outbreak.
Escaping the Ship: The ship starts to self-destruct. Escape through a collapsing corridor, using platforms and boosters to navigate the chaos.
Reuniting with Dani (Optional): Depending on your choices, you may encounter Dani here. This encounter can have consequences for the story’s ending.
The Colony
Underground Colony: You’ll find yourself in an underground colony seemingly unaffected by the Biophage outbreak.
Following Elias: Encounter Elias, a suspicious character who offers information about the situation. Follow him cautiously.
Blackened: Reach a quarantined area filled with “Blackened” humans – mutated individuals retaining some semblance of humanity.
Moral Choice: You’ll face a moral choice that can affect the ending. Choose to help the Blackened or prioritize your own survival.
Rejoining Elias: After navigating the quarantined area, regroup with Elias. He’ll provide you with a new weapon – the SK WS shotgun.
The Truth
Uncovering the Conspiracy: Explore the colony and access terminals to uncover the truth behind the Biophage outbreak and the prison’s dark secrets.
S.C.U. Facility: Infiltrate the Special Containment Unit (S.C.U.) facility, encountering heavily armed security forces and mutated creatures.
The Sprawl: Navigate the Sprawl, a vast network of tunnels teeming with Biophages. The SK WS shotgun is effective against large groups of enemies.
Biomass Spreader: Locate and destroy a Biomass Spreader, a machine propagating the Biophage outbreak. Use a combination of weapons and environmental objects to achieve this.
Encounter with Dr. Carver: You’ll encounter Dr. Carver, the head of the S.C.U. facility. A cutscene reveals his role in the events and sets the stage for the next chapter.
The Furies
Factory Breakout: Escape the collapsing S.C.U. facility, dodging falling debris and battling Biophages.
The Furies: Enter a dark and disturbing area called The Furies. Expect grotesque mutated creatures and unsettling environmental hazards.
Fire Ax Acquisition: You’ll acquire a powerful fire ax – a great weapon for close-quarters combat and dismembering enemies.
Biomass Canisters: Locate and destroy glowing red Biomass canisters to weaken the area’s mutations and progress.
Boss Fight: The Alpha Prepare to face a hulking mutated monstrosity known as The Alpha. Use a combination of weapons, dodging, and environmental objects to defeat it.
Ascension
Escaping the Nest: The Nest starts to collapse. Escape the crumbling structure, avoiding falling debris and mutated creatures.
Reaching the Surface: Ascend through an elevator shaft, witnessing the true scale of the Biophage outbreak on Callisto.
Choices and Consequences: Depending on your choices throughout the game, you’ll face different final encounters and decisions with lasting consequences.
Multiple Endings: The Callisto Protocol offers multiple endings based on your actions and choices. Explore different playthroughs to experience them all.
FAQs
Does The Callisto Protocol have multiple endings?
Yes, the game offers multiple endings depending on your choices throughout the story.
Are there any missable collectibles?
Yes, there are various collectibles scattered throughout the game. Consult online resources for detailed missable collectible guides.
What difficulty should I play on for my first playthrough?
This depends on your experience with action horror games. For a balanced experience, the standard difficulty is a good starting point.
Is there any post-game content?
Aside from the optional epilogue chapter, there isn’t any extensive post-game content. However, you can replay the story on a higher difficulty or aim for a different ending.
The Callisto Protocol delivers a brutal and suspenseful journey through a nightmarish prison on Jupiter’s moon. This walkthrough provided a roadmap through the main story, highlighting key objectives, combat encounters, and exploration opportunities. Remember, exploration and resource management are crucial for survival.
Following these tips and the provided walkthrough can help you navigate the horrors of Black Iron Prison and uncover the dark secrets of the Callisto Protocol. However, the true thrill lies in experiencing the story’s twists and turns, the intense combat, and the unsettling atmosphere for yourself. So, grab your weapons, conserve your resources, and prepare to face the horrors of Callisto.
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